Micronucleus assay in genotoxicity assessment
نویسندگان
چکیده
منابع مشابه
Genotoxicity Assessment of Acrylamide in Early Developing Stages of Chick Embryo Using Micronucleus Assay
The micronucleus (MN) test in bone-marrow and peripheral blood erythrocytes is one of the best established in vivo cytogenetic assays in the field of genetic toxicology, providing a convenient and reliable index of both chromosome breakage and chromosome loss. Therefore a study was made on micronuclei assay to evaluate the degree of genotoxicity of acrylamide and its toxicologic effects on chic...
متن کاملAssessment of Genotoxicity Among Rubber Industry Workers Occupationally Exposed to Toxic Agents Using Micronucleus Assay
BACKGROUND Occupational and environmental exposures mostly represent complexmixture of genotoxic agents, however there is a wide variation in the specificity of biomarkers. Exploration of correlations among biomarkers contributes to the further progress of molecular cancer epidemiology and to the selection of the optimal biomarkers for the investigation of human exposure to carcinogens. The aim...
متن کاملassessment of genotoxicity among rubber industry workers occupationally exposed to toxic agents using micronucleus assay
background: occupational and environmental exposures mostly represent complex mixture of genotoxic agents, however there is a wide variation in the specificity of biomarkers. exploration of correlations among biomarkers contributes to the further progress of molecular cancer epidemiology and to the selection of the optimal biomarkers for the investigation of human exposure to carcinogens. the a...
متن کاملMicronucleus cytome assay in the differential assessment of cytotoxicity and genotoxicity of cadmium and lead in Amietophrynus regularis
Amphibians are increasingly being used as bio-indicator of contamination in ecosystems due to their sensitivity to xenobiotics in the environment. Cadmium and lead compounds, ubiquitous mutagens and carcinogens, are capable of eliciting genome instability in adult toads which may enhance amphibian decline. Micronucleus cytome (MN-cyt) assay, a comprehensive cytogenetic test for the assessment o...
متن کاملAssessment of cyto/genotoxicity of irinotecan in v79 cells using the comet, micronucleus, and chromosome aberration assay.
Irinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 microg mL-1), recommended monotherapy dose (9 microg mL-1), and recommended combined therapy dose (4.5 microg mL-1) of irinotecan were studied on V79 cells using the comet assay, chromosome aberration assay, and micronucleus test. ...
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ژورنال
عنوان ژورنال: Acta fytotechnica et zootechnica
سال: 2016
ISSN: 1336-9245
DOI: 10.15414/afz.2016.19.si.93-95